- Johnstone教授及其团队将基于相位OCT的研究作为一个特殊的平台 , 可以定量刻画人类小梁网的活动 。 该相位OCT技术可发现青光眼患者的小梁网活动异常 , 有望根据此特征区分正常人群和青光眼患者 。
- 此外 , Johnstone教授及其团队还发现了房水流出组织结构是一个组织精美的器官系统 , 高度统一 。
- 通过将看似不相关的信息与临床研究联系起来(例如裂隙灯和房角镜检查程序 , 以及组织、细胞和亚细胞水平的实验室研究) , 能够找到青光眼发病的模式 , 并解释和预测房水流出 。
- 青光眼引起搏动性的房水流出异常 , 而治疗青光眼的药物可以恢复房水正常的脉动流 。
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It’s been a very exciting time. Our laboratory has developed a series of experimental platforms to explore the behavior of the outflow system, primarily distal to the trabecular meshwork. We have a number of techniques that we use, including scanning electron microscopy. We use confocal microscopy, tracer studies – and a series of other techniques. And what we have discovered is that the trabecular meshwork moves very dynamically.
Schlemm’s canal turns out to be a collapsible chamber with what looks like inlet and outlet valves. With very high-resolution OCT, we can demonstrate pressure dependant motion of the trabecular meshwork in these inlet and outlet valves. We have studies involving phase-based OCT as a special platform now that can quantitate trabecular meshwork motion in humans. This phase OCT technology has found that the trabecular meshwork motion becomes abnormal in glaucoma patients. We can separate normal from glaucoma patients based on that motion. So, we’re very excited about that.
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