免疫|CD：新型细胞内免疫检查点诞生，抗癌效果或超PD-1抑制剂( 三 ) fl|细胞|Tiganis|抗癌|研究|抑制剂

值得一提的是， Tiganis团队还发现，PTP1B缺失或抑制也能促进CAR-T细胞的效应功能和向实体瘤的浸润，增强CAR-T细胞对实体瘤的抑制能力。
总而言之，此项研究为肿瘤免疫治疗寻找到一个新的细胞内免疫检查点，证明靶向PTP1B可以提高CTL的杀伤功能，促进T细胞向效应或记忆表型分化，增加TIL数量。让人眼前一亮的是，小鼠实验表明， PTP1B抑制剂的效果优于PD-1抑制剂，而且PTP1B抑制剂联合PD-1抑制剂还能发挥1+1＞2的效果。
在未来， PTP1B抑制剂与PD-1抑制剂联合使用，或许能解决PD-1抑制剂的耐药性问题，将免疫细胞浸润少的“冷肿瘤”转化为炎症型的“热肿瘤”从而更好的响应免疫治疗。
此外， PTP1B这个细胞内的免疫检查点，也有可能成为CAR-T治疗实体瘤的突破口。

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