预防流感的有效方法,流感鼻喷疫苗您有了解吗?( 三 )


与免前相比 , 80-100%的受试者的鼻腔灌洗液中检出了针对疫苗株的特异性黏膜IgA≥2倍增长 。
受试者的黏膜IgA抗体分泌的峰值时间从第1天到第10天不等 , 黏膜IgA中位峰值时间为接种3天后 。
参考文献:
戴玮真,陈美珠,翟梅英.情绪干预对儿童预防接种疼痛及恐惧的影响.海峡预防医学杂志,2017,23(3):95-97.
GarraG,SingerAJ,DomingoA,etal.TheWong-BakerpainFACESscalemeasurespain,notfear.PediatricEmergencyCare,2013,29(1):17-20.
MohnKG,SmithI,SjursenH,etal.Immuneresponsesafterliveattenuatedinfluenzavaccination.HumVaccinImmunother.2018;14(3):571-578.
郑眉.基于流感病毒保守抗原的广谱流感疫苗研究进展.国际生物制品学杂志,2019,42(4):198-202.
MohnKG,BrokstadKA,IslamS,etal.EarlyInductionofCross-ReactiveCD8+T-CellResponsesinTonsilsAfterLive-AttenuatedInfluenzaVaccinationinChildren.JInfectDis.2020;221(9):1528-1537.
HammittLL,BartlettJP,LiS,etal.Kineticsofviralsheddingandimmuneresponsesinadultsfollowingadministrationofcold-adaptedinfluenzavaccine.Vaccine,2009,27(52):7359-7366.
WorldHealthOrganization.(?2015)?.TheGlobalActionPlanforinfluenzavaccines:reportofthetenthmeetingoftheAdvisoryGroupoftheWHOGlobalActionPlanforInfluenzaVaccines.WorldHealthOrganization.https://apps.who.int/iris/handl