Peinado|《自然》子刊：癌细胞转移前就把“黑手”伸进了淋巴管！科学家发现，黑色素瘤细胞会释放外泌体改造淋巴管，促进肿瘤转移丨科学大发现( 三 ) 团队|黑手|改造|研究|癌细胞

参考文献：
[1]Peinado, H. et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883–891 (2012).
[4]Sleeman, J. P. Te lymph node pre-metastatic niche. J. Mol. Med. 93, 1173–1184 (2015).
[5]Ghislin, S. et al. LFA-1 and ICAM-1 expression induced during melanoma–endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro. BMC Cancer 12, 455 (2012).
[6]Sun, B. et al. Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes. Int. J. Cancer 145, 1648–1659 (2019).
[7]Boiko, A. D. et al. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature 466, 133–137 (2010).
[8]Restivo, G. et al. Te low neurotrophin receptor CD271 regulates phenotype
switching in melanoma. Nat. Commun. 8, 1988 (2017).
[9]Civenni, G. et al. Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res. 71, 3098–3109 (2011).
【Peinado|《自然》子刊：癌细胞转移前就把“黑手”伸进了淋巴管！科学家发现，黑色素瘤细胞会释放外泌体改造淋巴管，促进肿瘤转移丨科学大发现】本文作者 | 张艾迪