阿德姆·帕塔普蒂安|解读丨“发现温度和触觉的受体”——2021年诺贝尔生理学或医学奖揭晓( 三 )


徐天乐为上海交通大学医学院特聘教授 , 朱曦为德克萨斯大学休斯敦健康医学中心教授 , 李海涛为清华大学医学院教授 。

参考文献:(上下滑动可浏览)
1.Cosens D. J., and Manning Aubrey. "Abnormal Electroretinogram from a Drosophila Mutant." Nature 224, no. 5216 (1969): 285-7.
2.Montell Craig, and Rubin Gerald M. "Molecular Characterization of the Drosophila Trp Locus: A Putative Integral Membrane Protein Required for Phototransduction." Neuron 2, no. 4 (1989): 1313-23.
3.Ferreira Gonzalo, Raddatz Natalia, Lorenzo Yenisleidy, González Carlos, and Latorre Ramón. "Biophysical and Molecular Features of Thermosensitive Trp Channels Involved in Sensory Transduction." 1-39: Springer International Publishing, 2015.
4.Baccaglini P. I., and Hogan P. G. "Some Rat Sensory Neurons in Culture Express Characteristics of Differentiated Pain Sensory Cells." Proc Natl Acad Sci U S A 80, no. 2 (1983): 594-8.
5.Caterina Michael J , Schumacher M A , Tominaga Makoto , Rosen Tobias A , Levine Jon D , and Julius David "The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway." Nature 389, no. 6653 (1997): 816-24.
6.Koivisto Ari-Pekka, Belvisi Maria G, Gaudet Rachelle, and Szallasi Arpad. "Advances in Trp Channel Drug Discovery: From Target Validation to Clinical Studies." Nat Rev Drug Discov(2021).
7.Mio Kazuhiro, Ogura Toshihiko, Kiyonaka Shigeki, Hiroaki Yoko, Tanimura Yukihiro, Fujiyoshi Yoshinori, Mori Yasuo, and Sato Chikara. "The Trpc3 Channel Has a Large Internal Chamber Surrounded by Signal Sensing Antennas." J Mol Biol 367, no. 2 (2007): 373-83.
8.Liao Maofu, Cao Erhu, Julius David, and Cheng Yifan. "Structure of the Trpv1 Ion Channel Determined by Electron Cryo-Microscopy." Nature 504, no. 7478 (2013): 107-12.
9.Cao Erhu, Liao Maofu, Cheng Yifan, and Julius David. "Trpv1 Structures in Distinct Conformations Reveal Activation Mechanisms." Nature 504, no. 7478 (2013): 113-8.
10.Jara-Oseguera Andres, Huffer Katherine E, and Swartz Kenton J. "The Ion Selectivity Filter Is Not an Activation Gate in Trpv1-3 Channels." Elife 8 (2019).
11.Castillo Karen, Diaz-Franulic Ignacio, Canan Jonathan, Gonzalez-Nilo Fernando, and Latorre Ramon. "Thermally Activated Trp Channels: Molecular Sensors for Temperature Detection." Phys Biol 15, no. 2 (2018): 021001.
12.Laursen Willem J, Schneider Eve R, Merriman Dana K, Bagriantsev Sviatoslav N, and Gracheva Elena O. "Low-Cost Functional Plasticity of Trpv1 Supports Heat Tolerance in Squirrels and Camels." Proc Natl Acad Sci U S A 113, no. 40 (2016): 11342-47.
13.Yao Jing, Liu Beiying, and Qin Feng. "Modular Thermal Sensors in Temperature-Gated Transient Receptor Potential (Trp) Channels." Proc Natl Acad Sci U S A 108, no. 27 (2011): 11109-14.
14.Brauchi Sebastian, Orta Gerardo, Salazar Marcelo, Rosenmann Eduardo, and Latorre Ramon. "A Hot-Sensing Cold Receptor: C-Terminal Domain Determines Thermosensation in Transient Receptor Potential Channels." J Neurosci 26, no. 18 (2006): 4835-40.
15.Vlachova Viktorie, Teisinger Jan, Susankova Klara, Lyfenko Alla, Ettrich Rudiger, and Vyklicky Ladislav. "Functional Role of C-Terminal Cytoplasmic Tail of Rat Vanilloid Receptor 1." J Neurosci 23, no. 4 (2003): 1340-50.
16.Brauchi Sebastian, Orta Gerardo, Mascayano Carolina, Salazar Marcelo, Raddatz Natalia, Urbina Hector, Rosenmann Eduardo, Gonzalez-Nilo Fernando, and Latorre Ramon. "Dissection of the Components for Pip2 Activation and Thermosensation in Trp Channels." Proc Natl Acad Sci U S A 104, no. 24 (2007): 10246-51.
17.Luo Lei, Wang Yunfei, Li Bowen, Xu Lizhen, Kamau Peter Muiruri, Zheng Jie, Yang Fan, Yang Shilong, and Lai Ren. "Molecular Basis for Heat Desensitization of Trpv1 Ion Channels." Nat Commun 10, no. 1 (2019): 2134.
18.Yang Fan, Cui Yuanyuan, Wang KeWei, and Zheng Jie. "Thermosensitive Trp Channel Pore Turret Is Part of the Temperature Activation Pathway." Proc Natl Acad Sci U S A 107, no. 15 (2010): 7083-8.