指导|《柳叶刀》：厉害了，中国科学家、中国技术！由中国专家牵头、基于中国技术、在中国完成的心血管领域随机对照临床试验首次登顶( 三 ) 治疗学|柳叶刀|病变|患者|临床

此外，该研究用QFR和造影进行比较，显示了QFR的益处，但究竟临床上是选用FFR还是QFR来作为PCI术前指导呢？这一问题还尚不清楚，而好消息是有一项临床研究（FAVOR III Europe-Japan）正在欧洲和日本进行，来比较FFR和QFR表现孰优，结果非常令人期待。

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指导PCI病变部位选择的相关临床研究小结示意图
总而言之， FAVOR III China是首个比较血管造影衍生的计算指标和标准血管造影指导PCI的临床结果的随机试验。与标准血管造影指导相比，QFR指导导致主要不良心脏事件1年发生率降低35% 。受益主要是由于心肌梗死减少(包括围手术期和非手术性心肌梗死)和缺血后血运重建减少，两组间死亡率相似。此外， QFR指导导致支架和造影剂的使用减少，患者辐射暴露减少，以及手术时间更短。
在PCI患者中，与标准的血管造影指导相比，QFR指导策略改善了1年的临床结果，同时减少了资源消耗。 QFR比基于导线的生理测量（FFR）更容易实现，这有助于将用生理指标评估病变部位的方法纳入常规临床实践。
对冠心病介入治疗临床实践而言，中度至重度狭窄、病变压力或血流没有明显下降的患者，可以安全地推迟PCI 。
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