感染新冠后失去嗅觉，原因找到了( 三 )

在多项新冠病毒疫苗的研究中，与未接种疫苗者相比，接种了至少全程疫苗的志愿者即使感染新冠病毒，出现包括嗅觉异常在内的症状的概率均更低，严重程度也更轻。此外，根据既往流感疫苗接种的经验来看[13] ，也不排除新冠病毒疫苗对新冠病毒感染诱发的长期嗅觉丧失具有一定预防作用。但截至目前，无论是预防还是治疗，都需要更多临床研究来检验它们的效果和价值。（策划：z_popeye｜监制：gyouza）
致谢：本文经遗传学博士、药企研发科学家周叶斌专业审核
题图来源：视觉中国
参考资料：
[1]EliezerM,HautefortC,HamelAL,etal.SuddenandCompleteOlfactoryLossofFunctionasaPossibleSymptomofCOVID-19.JAMAOtolaryngolHeadNeckSurg.2020;146(7):674-675.doi:10.1001/jamaoto.2020.0832
[2]GiacomelliA,PezzatiL,ContiF,etal.Self-reportedOlfactoryandTasteDisordersinPatientsWithSevereAcuteRespiratoryCoronavirus2Infection:ACross-sectionalStudy.ClinInfectDis.2020;71(15):889-890.doi:10.1093/cid/ciaa330
[3]YanCH,FarajiF,PrajapatiDP,etal.AssociationofchemosensorydysfunctionandCOVID-19inpatientspresentingwithinfluenza-likesymptoms.IntForumAllergyRhinol.2020;10(7):806-813.doi:10.1002/alr.22579
[4]MoeinST,HashemianSM,MansourafsharB,etal.Smelldysfunction:abiomarkerforCOVID-19.IntForumAllergyRhinol.2020;10(8):944-950.doi:10.1002/alr.22587
[5]Boscolo-RizzoP,TirelliG,MeloniP,etal.Coronavirusdisease2019(COVID-19)-relatedsmellandtasteimpairmentwithwidespreaddiffusionofsevereacuterespiratorysyndrome-coronavirus-2(SARS-CoV-2)Omicronvariant.IntForumAllergyRhinol.2022;12(10):1273-1281.doi:10.1002/alr.22995
[6]deMeloGD,LazariniF,LevalloisS,etal.COVID-19-relatedanosmiaisassociatedwithviralpersistenceandinflammationinhumanolfactoryepitheliumandbraininfectioninhamsters.SciTranslMed.2021;13(596):eabf8396.doi:10.1126/scitranslmed.abf8396
[7]BrannDH,TsukaharaT,WeinrebC,etal.Non-neuronalexpressionofSARS-CoV-2entrygenesintheolfactorysystemsuggestsmechanismsunderlyingCOVID-19-associatedanosmia.SciAdv.2020;6(31):eabc5801.doi:10.1126/sciadv.abc5801
[8]ChenM,ShenW,RowanNR,etal.ElevatedACE-2expressionintheolfactoryneuroepithelium:implicationsforanosmiaandupperrespiratorySARS-CoV-2entryandreplication.EurRespirJ.2020;56(3):2001948.doi:10.1183/13993003.01948-2020
[9]FinlayJB,BrannDH,AbiHachemR,etal.Persistentpost-COVID-19smelllossisassociatedwithimmunecellinfiltrationandalteredgeneexpressioninolfactoryepithelium.SciTranslMed.2022;14(676):eadd0484.doi:10.1126/scitranslmed.add0484
[10]KaramaliK,ElliottM,HopkinsC.COVID-19relatedolfactorydysfunction.CurrOpinOtolaryngolHeadNeckSurg.2022;30(1):19-25.doi:10.1097/MOO.0000000000000783
[11]LiuDT,SabhaM,DammM,etal.ParosmiaisAssociatedwithRelevantOlfactoryRecoveryAfterOlfactoryTraining.Laryngoscope.2021;131(3):618-623.doi:10.1002/lary.29277
[12]DeWeerdtS.Howtobringbackthesenseofsmell.Nature.2022:606,S7-S9.doi:10.1038/d41586-022-01628-9
[13]FlanaganCE,WiseSK,DelGaudioJM,etal.Associationofdecreasedrateofinfluenzavaccinationwithincreasedsubjectiveolfactorydysfunction.JAMAOtolaryngolHeadNeckSurg.2015;141(3):225-8.doi:10.1001/jamaoto.2014.3399